CD8A and neoplasm: Analysis of data from The Cancer Genome Atlas (TCGA) public database revealed that RNF125 expression levels are positively correlated with the infiltration of CD4+ and CD8+ T cells, as well as macrophages, within tumors (57).WD repeat 4 (WDR4) has been reported to be a substrate junction for CRL, which can degrade a tumor suppressor, the promyelocytic leukemia (PML) protein.In this process, the expansion of Treg cells, M2 macrophages, and the reduction of CD8+ T cells contribute to the establishment of an immunosuppressive and pro-metastatic TME (58).