In QGY7703 and SMMC7721 hepatoma cell lines, siRNA-mediated NEDD4 knockdown assays showed that decreased expression of NEDD4 inhibited cell proliferation, invasion, and migration, promoted apoptosis, and further supported the role of the NEDD4-LATS1 pathway in HCC progression (42). Here, LATS1 is linked to hepatocellular carcinoma.