CD4 and experimental autoimmune encephalomyelitis: It was found that the m6A-modifying demethylase ALK-BH5 promotes IFN-γ and CXCL2 mRNA stability in CD4+ T cells, which in turn enhances CD4+ T cell pathogenicity in experimental autoimmune encephalomyelitis (EAE), whereas the demethylase FTO does not function (41).