In addition, imperatorin acts as a Takeda G-protein-coupled receptor 5 (TGR5) and G-protein-coupled receptor 119 (GPR119) agonist, inducing glucagon-like peptide (GLP-1) secretion and lowering blood glucose levels in type 1 diabetic rats through activation of TGR5 and GPR119 (105). This evidence concerns the gene GPBAR1 and type 1 diabetes mellitus.