Plumbagin has been shown to reduce the levels of TNF-α, IL-6 and matrix metalloproteinases (MMPs) in RA mouse cells by inhibiting NF-κB activation, and its mechanism of action is related to the inhibition of IκB and NF-κB activation as well as the entry of p65 into the cell nucleus (142). The gene discussed is NFKB1; the disease is rheumatoid arthritis.