Plumbagin significantly inhibited the phosphorylation of STAT1, STAT4, and STAT3, as well as the upstream kinases JAK1 and JAK2, resulting in a reduction in the number of CD4+ T-lymphocytes and pro-inflammatory cytokines in mice with experimental autoimmune encephalomyelitis, which ameliorated the locomotor dysfunction and body weight loss of mice (170). The gene discussed is CD4; the disease is experimental autoimmune encephalomyelitis.