AKT1 and endometriosis: It was confirmed that imperatorin significantly inhibited the activation of the PI3K/AKT/NF-κB pathway by inhibiting the phosphorylation levels of PI3K, AKT, and p65 in the ectopic endometrium tissue, thereby significantly inhibiting the growth and ameliorate the histopathological features of ectopic endometrium in experimental endometriosis rats (153).