For example, in the collagen-induced RA mouse model, columbianadin can play an anti-RA role by regulating inflammation and oxidative stress, and its mechanism includes inhibiting the expression of Keap1 at mRNA and protein levels, increasing the expression of Nrf2 mRNA in CIA mice, regulating Keap1/Nrf2 signaling pathway in CIA mice, and inhibiting the activation of NF-κB (157). Here, KEAP1 is linked to rheumatoid arthritis.