Furthermore, in FLS from RA rats, Umbelliferone could reduce the activation of the Wnt/β-catenin pathway by restoring GSK-3β activity, reducing the levels of pathway-associated proteins (e.g., Wnt1, LRP6, p-GSK-3β (Ser 9), β-catenin, cyclin D1, and c-Myc), and inhibiting β-catenin nuclear translocation (164). This evidence concerns the gene GSK3B and rheumatoid arthritis.