In addition, in mice models of CIA, colombianadin was able to exert anti-RA effects by modulating immune and inflammatory responses, and its mechanism of action included decreasing the phosphorylation levels of JAK1 and STAT3 in the ankle joints of mice with CIA as well as the STAT3 mRNA expression, suggesting that colombianadin attenuates inflammatory responses by inhibiting the JAK1/STAT3 pathway. Here, STAT3 is linked to rheumatoid arthritis.