TLR8 and Cowden syndrome 1: Given the distinctive gene expression pattern and intriguing function of TLR8-expressing macrophages shown in the microarray and scRNA-seq analyses, we screened LSG tissues from SjD patients and SMG tissues from CS patients with CD68+ macrophage infiltration and performed multi-color IF staining using these tissue sections from SjD (n = 19) and CS (n = 6) patients.