MAPK3 and melanoma: More importantly, our data evidently supported a strong influence of E2F1 and its target IL-6 on the Th1/Th2 development like Th2 cytokine production (Figure 1H), downregulation of ERK1/2 pathways, IFN-γ response (Figure 3F, bottom), or CCL2 expression in melanoma cells (Figure 3G).