Through integration of logic-based network modeling and gene expression profiling of cancer cell lines from E2F1-driven tumors and patient cohorts with aggressive cancer, tumor type-specific receptor signatures associated with EMT were found, in which the combined activity of high E2F1, TGFBR1, and FGFR1 triggers the most invasive phenotype (15). The gene discussed is E2F1; the disease is neoplasm.