Through integration of logic-based network modeling and gene expression profiling of cancer cell lines from E2F1-driven tumors and patient cohorts with aggressive cancer, tumor type-specific receptor signatures associated with EMT were found, in which the combined activity of high E2F1, TGFBR1, and FGFR1 triggers the most invasive phenotype (15). This evidence concerns the gene TGFBR1 and cancer.