ACHE and Alzheimer disease: In this study, specific subsets of DC, namely myeloid DC were found depleted in the blood of AD patients however that was not observed when the patients were under AD treatment with acetylcholinesterase inhibitors (Ciaramella et al., 2016); elsewhere both subpopulations of DCs were found increased in both cognitively normal and patients with MCI who were amyloid positive (Grayson et al., 2023).