SOD2 and obesity due to melanocortin 4 receptor deficiency: With regards to inflammatory state and oxidative stress, mulberry has shown to reduce inflammatory markers related to obesity, such as TNF-a and IL-6 and decrease oxidative stress, by increasing antioxidant enzymes, such as heme oxygenase (HO-1), glutathione peroxidase (GPx) and manganese superoxide dismutase (MnSOD) (70, 73–75) (Table 3).