TP53 and neoplasm: For this reason, diagnostic criteria for this tumor have been proposed, the main pathological findings in this tumor are squamous proliferations without atypia of the keratinocytes, sinuses, and crypts deep to the skin surface lined with epithelium, these crypts contain laminated keratin .2Nakamura et al have discussed the role of mutated p53 as a tool to aid differentiation between this tumor and the verrucous lesions of the diabetic foot.13In our case report, a p53 strain was employed by the pathologist which helped achieve the final diagnosis.