GPT and Gilbert syndrome: In absence of liver metastases, ALT and AST ≤2.5 × ULN. With liver metastases, ALT and AST <5 × ULN, total bilirubin ≤ULN, or total bilirubin 1.5 × ULN with direct bilirubin ≤ULN of the laboratory in subjects with documented Gilbert’s syndrome