SERPINE1 and hepatocellular carcinoma: Jin et al., (2020) reported significantly higher SERPINE1 expression in HCC tissues compared to adjacent non-cancerous tissues, with a negative correlation between SERPINE1 expression and overall survival, suggesting its prognostic value (Jin et al., 2020). SERPINE1 has been shown to promote proliferation, migration and invasion in HepG2 cells (Li et al., 2021b). Conversely, our findings demonstrate that SERPINE1 knockdown enhances proliferation and invasion in Huh7 cells, indicating the heterogeneous nature of SERPINE1 expression and function within HCC cells.