Overexpressed in various cancers, including gastric (Chen et al., 2022; Tutunchi et al., 2021), lung (Hong et al., 2022; Setiawan et al., 2024), and colon (Wang et al., 2023b) cancers, SERPINE1 is classified as a pan-oncogene and is associated with poor prognosis (Ju et al., 2024). The gene discussed is SERPINE1; the disease is cancer.