For instance, CAF-derived exosomal miR-20a-5p promotes HCC progression through the LIMA1-mediated β-catenin pathway (Qi et al., 2022), while CAF-derived exosomal miR-1228-3p enhances the resistance of liver cancer cells to sorafenib (Zhang, Pan & Shao, 2023). The gene discussed is LIMA1; the disease is liver cancer.