Dysfunction in the autophagy-lysosomal pathway of neurons, as seen in diseases like Alzheimer’s, leads to exosomal uptake of lysosomal membrane proteins and lysosomal granule enzyme cathepsin D. Consequently, levels of LAMP-1 are elevated in neural-derived plasma exosomes from patients with AD compared to those without the disease, as will be commented below (Goetzl et al., 2015). This evidence concerns the gene LAMP1 and Alzheimer disease.