MAPT and Alzheimer disease: In the pathogenesis of AD, the neurofibrillary tangles formed are the result of hyperphosphorylation of the Tau protein mediated by ROS, which can stimulate Tau protein hyperphosphorylation and disrupt calcium homeostasis in neuronal cell membranes, inducing the process of apoptosis (Guan et al., 2021; Ge et al., 2022).