However, more studies reported contradictory findings in which genetic manipulation of Lkb1 in mouse tissues did not promote prostate cancer (Hermanova et al., 2020), bladder cancer (Shorning et al., 2011), serous ovarian cancer (Tanwar et al., 2014), lung cancer (Ji et al., 2007), melanoma (Liu et al., 2012) or endometrial cancer (Cheng et al., 2014). Here, STK11 is linked to Familial prostate cancer.