Despite inhibiting the proliferation of tumor cells, DOX could also promote wound healing and invasion ability of breast cancer cells by inducing EMT via regulation several factors including TGF-β, NF-kB, Twist1, Snail (Chen et al., 2013; Li Q. Q. et al., 2011; Li et al., 2009; Li W. et al., 2011). This evidence concerns the gene SNAI1 and breast cancer.