In humans, the NLRP3 inflammasome has been strongly associated with tubulointerstitial injury/fibrosis and CKD progression (Vilaysane et al., 2010; Ermer et al., 2016; Darisipudi and Knauf, 2016; Shahzad et al., 2015; Anders and Muruve, 2011; Granata et al., 2015). This evidence concerns the gene NLRP3 and chronic kidney disease.