CASP8 and chronic kidney disease: The primary functional role of apoptosis-related molecules in CKD may, in fact, be mediated through their interactions with other regulated necrosis pathways, with activation of caspase-8 during apoptosis shown to inhibit necroptosis, but also trigger pyroptosis (Pang and Vince, 2023; Oberst et al., 2011) (outlined in more detail in subsequent sections).