et al., 2022), oxalate nephropathy (Ludwig-Portugall et al., 2016), adenine-induced CKD (Ludwig-Portugall et al., 2016) and UUO (Seo et al., 2019), while Gsdmd deletion is shown to alleviate fibrosis in experimental models of obstructive nephropathy (Wang Y. et al., 2022) and APOL1-associated podocytopathy (Wu J. et al., 2021). The gene discussed is APOL1; the disease is chronic kidney disease.