CASP8 and chronic kidney disease: Further interrogation of RIPK3 function in CKD is needed, including: (i) the role of the caspase-8/RIPK3 signalling axis in regulating the delicate balance between non-inflammatory apoptosis and pro-inflammatory necroptosis (Xu and Huang, 2022); (ii) ZBP1 function in RIPK3 activation during viral-associated nephropathies; and (iii) how RIPK3 may trigger inflammation, independently of necroptosis – i.e., through activation of nuclear factor-κB (NF-κB) or the inflammasome (Moriwaki et al., 2017).