KL and hyperinsulinemic hypoglycemia, familial, 4: A fitted linear regression model (Table 5) to determine influence of different grades of s.Klotho deficiency on 1-year outcomes has predicted that patients with Grade 1 Klotho deficiency have < 2% GFR fall, Grade 2 Klotho deficiency have 2%–13% fall in GFR, Grade 3 Klotho deficiency have 13%–24% fall in GFR, and Grade 4 Klotho deficiency have > 24% predicted fall in GFR.