KMT2C and cancer: Then, two relevant germline variants were identified—NC_000018.9:g.22805738T>C (NM_015461:p.Asp715Gly, rs1390185292) in the ZNF521 and NC_000007.13:g.15197085856T>A (NM_170606:p.Thr316Ser, rs10454320) in the KMT2C. Both variants were assessed as “variants of uncertain significance” according to the joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC) (19).