Despite that the safety and relative tolerability of statins are proven by several studies including observational studies (8–13), clinical trials (14, 15) and meta-analyses (16–22), emerging evidence indicates that statins can increase the onset of type 2 diabetes (T2D) due to a reduction in insulin sensitivity and a decrease in β-cells mass and function in a dose-dependent manner. Here, INS is linked to type 2 diabetes mellitus.