NOTCH1 and central nervous system cancer: In brief, the T+A@Glu‐NPs is a novel and potential combined strategy for glioma chemotherapy and the sensitization of glioma chemotherapy by T+A@Glu‐NPs through modulation of Notch1 is a novel and main mechanism, offering a new direction for the development of new glioma chemotherapeutic regimens and providing more options for clinical glioma treatment.