Second, upon injection of CD4+ T cells, NSG mice developed signs of skin inflammation (alopecia), and Th17s were found at greater levels in the skin than in the spleen (~ 2-fold) [107]; this alopecia developed faster when transplanting NSG mice transgenic for the Th17-promoting cytokines IL-1β and IL-23 199. Here, CD4 is linked to alopecia.