MCL1 and non-small cell lung carcinoma: To explore whether the interaction of MDM2 and FBW7 constituted the mechanistic basis for MDM2-mediated MCL-1 stabilization and Osimertinib resistance in NSCLC, we screened in silico prediction and literature reports and noticed a consensus recognition motif enriched in glutamine (Q) across a panel of MDM2 substrates.