We evaluated the expression of MDM2 and FBW7 in 23 cases of surgical resected NSCLC by IHC staining and found that the MDM2low tumors tended to have a relative higher expression level of FBW7, whereas FBW7 expression in the MDM2high tumors was largely diminished (Fig. 7H). This evidence concerns the gene FBXW7 and non-small cell lung carcinoma.