Consistent with a role as E3 ubiquitin ligase, overexpression of MDM2 accelerated the turnover of FBW7 protein in multiple NSCLC cell lines, along with the stabilization of proteins targeted by FBW7, such as MCL-1, cyclin E and c-Myc (Fig. 4C). This evidence concerns the gene MCL1 and non-small cell lung carcinoma.