RUNX1 and acute myeloid leukemia: Retroviral transduction of URE-AML cells with a dominant-negative form of RUNX (dnRUNX, (Sun et al, 2001)) to block activity of RUNX1 (and potentially redundant RUNX2/3), led to downregulation of the aforementioned genes (Fig. 7F), providing proof that RUNX is required for their expression.