In this study, we found that overexpression of MDM4 in mutant p53 colon cancer cells was able to increase the expression level of GPX4, and knockdown of MDM4 was followed by a decrease in the protein expression level of GPX4, which also provided strong evidence for the conclusion that MDM4 inhibited ferroptosis in mutant p53 colon cancer. The gene discussed is TP53; the disease is colonic neoplasm.