Overexpression of MDM4 increased the GSH/GSSG ratio (Figs. 2D and S2C), resisted RSL3-induced ROS accumulation (Figs. 2E and S2D), and decreased MDA content (Figs. 2F and S2E) in p53 mutant colon cancer cells. This evidence concerns the gene TP53 and colonic neoplasm.