Overexpression of MDM4 increased the GSH/GSSG ratio (Figs. 2D and S2C), resisted RSL3-induced ROS accumulation (Figs. 2E and S2D), and decreased MDA content (Figs. 2F and S2E) in p53 mutant colon cancer cells. Here, TP53 is linked to malignant colon neoplasm.