In cancers, whether targeting the TNFR1 pathway would be viable remains unknown, although it should be noted that TNFR2 promotes the suppressive function of regulatory T cells13,54, so while preserving TNFR2 over TNFR1 signaling may improve NK cell responses, it may also promote immunosuppression. This evidence concerns the gene TNFRSF1A and cancer.