GLA and Fabry disease: FD is an X-linked lysosomal storage disorder (LSD).351 Its root cause lies in the pathogenic mutation of the GLA gene (Xq21.3-q22), which leads to a loss of enzyme activity encoding lysosomal enzyme α-galactosidase A. This results in abnormal metabolism of related glycolipids and the subsequent accumulation of glycolipids throughout the body, causing structural damage and functional loss in various tissues and organs, particularly affecting the heart, kidney, and nervous system.