CD8A and neoplasm: The immune system is intricately interconnected with cancer treatment, and variations in hormonal and X chromosome gene expression can lead to different immune responses among distinct populations of innate and adaptive immune cells.424 For example, in patients with KRAS mutations in lung adenocarcinoma, females demonstrate a greater abundance of CD4+ T and CD8+ T cells compared to males.425 The study conducted by Thompson et al.426 revealed variations in the functionality of the transcription factor FOXO3, which is associated with tumor-infiltrating DCs tolerance, between genders.