CD8A and neoplasm: In addition, also for the treatment of viral-associated tumor diseases, such as HPV-associated cervical cancer, Ling et al.326 designed a pH-responsive nonviral nano-carrier to deliver Cas9 mRNA and the guide RNAs (gRNAs) of oncogenes E6 and E7 that target HPV, which can effectively knock out the E6/E7 oncogenes, reverse the tumor’s immunosuppressive environment, and promote CD8+ T-cell survival.