Moreover, we found that flubendazole binds tightly with xCT and TFRC, further revealing that the two central mediators of ferroptosis including p53/xCT/GPX4 and TFRC/DMT1/FHC signalling pathways are both accounting for ferroptosis‐inducing ability of flubendazole in GBM. Here, GPX4 is linked to glioblastoma.