These data demonstrated that CPZ resulted in the down-regulation of mRNA levels of MBP expression (a marker of oligodendrocyte maturity), along with the up-regulation of mRNA levels of MMP-9, TNF-α, and S100β (markers of inflammation) that are related to MS; treatment of CPZ-rats with IONP-BBN was more effective in downregulating MS-related genes than free BBN (Fig. 9). This evidence concerns the gene TNF and myeloid sarcoma.