CPZ and Peripheral demyelination: CPZ-associated neurotoxicity affects both genders of rodents, but the effect is more aberrant in males, CPZ-induced rodent model of demyelination could represent an excellent MS experimental model to study CPZ-induced neurotoxicity and peripheral neuropathy (Ünsal and Özcan 2018), and to investigate myelin protection and remyelination after drug intervention (Yamamoto et al. 2014).