Differences between NHW and NHB women with breast cancer are reflected at the molecular level, including higher expression of mitotic kinases, alterations in the p53 and the BRCA1 networks, less PI3C mutations, higher levels of aneuploidy and prevalent immune and basal signatures in NHB women with breast cancer [49, 51–54]. The gene discussed is BRCA1; the disease is breast carcinoma.