The novel isoform of FOXM1 has been shown to directly interact with ROCK2, thereby activating Rho/ROCKs signaling, which further promotes actin polymerization and impedes E-cadherin expression, ultimately culminating in epithelial-mesenchymal transition (EMT) and metastasis in CRC (Zhang et al. 2016). The gene discussed is ROCK2; the disease is colorectal carcinoma.