Even though their time-dependent effects have not been characterized in detail, SKIL and SKI are known to be repressors of the TGFβ-induced gene expression response (Tecalco-Cruz et al, 2018), which control EMT in non-small cell lung cancer (Yang et al, 2015) and metastasis in breast cancer cells (Le Scolan et al, 2008). The gene discussed is SKIL; the disease is breast cancer.