ZBTB9 and obesity due to melanocortin 4 receptor deficiency: Although much remains to be discovered about the underlying molecular mechanism as well as the physiological role of ZBTB9 in adiposity, our study provides new mechanistic insights into how ZBTB9 regulates early adipogenesis and adipocyte function, identifying a new molecule that may be important in the pathogenesis and treatment of obesity and T2D.