These childhood cancers have a low mutational rate, and all cases of rhabdoid tumors present mutations in mSWI/SNF (mammalian SWItch/sucrose nonfermentable) subunits: more than 95% in SMARCB1 and the remaining in SMARCA4 (3, 4, 5, 6). Here, SMARCB1 is linked to childhood malignant neoplasm.