Although Ccl2 is known to be a major contributor to the recruitment of liver monocyte-derived macrophages (MDMs) to sites of liver injury and to promote fibrosis, the relative contribution of hepatocyte-derived Ccl2 to NASH pathogenesis and the underlying mechanism of Ccl2 expression in hepatocytes is relatively unknown. The gene discussed is CCL2; the disease is metabolic dysfunction-associated steatohepatitis.