KMT2D and metabolic dysfunction-associated steatohepatitis: To further dissect the cell types in which MLL4 functions to promote NASH, we first generated hepatocyte-specific Mll4 knockout mice, the Mll4f/f; Albumin-Cre (Mll4-AKO), by crossing Mll4f/f mice with Mll4f/+;Albumin-Cre mice.