TNF and hepatocellular carcinoma: Reactive oxygen species (ROS)-induced hepatocellular damage and the development of chronic inflammation linked to hepatocarcinogenesis occur prior to the induction of HCC [4]. The HCC has been defeated by adjuvant treatments such as doxorubicin, interferon alpha, and 5-FU; or tumor necrosis factor and melphalan; or cisplatin, epirubicin, and 5-FU [5].