Among the stromal genes (SI Appendix, Fig. S5B), we note that the everolimus+SNX631 combination upregulated an angiogenesis inhibitor Tnmd and putative tumor-suppressive proteins Acaca, Per3, and Ccl11, whereas Aldh1a2, a tumor stimulating stromal factor, was downregulated by the combination. Here, PER3 is linked to neoplasm.