We found a panel of proteins unique to sleep deprivation (Gsta4, Gstm2, Gstp1, Gstm1, Glo1, and Gstm5), validated several AD markers (e.g., App, Mapt, Bin1, and Igf1), and found numerous proteins reflecting an AD potentiated phenotype72 after sleep deprivation (e.g., Chit1, Got1, Ywhag, and Ywhae). This evidence concerns the gene BIN1 and Alzheimer disease.