We found a panel of proteins unique to sleep deprivation (Gsta4, Gstm2, Gstp1, Gstm1, Glo1, and Gstm5), validated several AD markers (e.g., App, Mapt, Bin1, and Igf1), and found numerous proteins reflecting an AD potentiated phenotype72 after sleep deprivation (e.g., Chit1, Got1, Ywhag, and Ywhae). Here, GSTM5 is linked to Alzheimer disease.