These are key processes involved in actively controlling the turnover of proteins and were previously described in AD pathology.59–61 Among the significantly regulated proteins, we also identified 26 murine orthologs with increased expression levels, which are listed among the top 65 proteins known to be altered in the CSF of AD patients (Figure 5F; Table S2).62 A noteworthy finding was the upregulation of insulin-degrading enzyme (Ide) in APP/PS1 mice subjected to sleep deprivation (Figure 5F). Here, APP is linked to Alzheimer disease.