Disrupted noradrenergic signaling contributes to AD progression and cognitive decline.28 NE is a key regulator of glymphatic flow; the high level of NE suppresses glymphatic activity during wakefulness, whereas the drop in NE levels during sleep facilitates brain clearance.7 NE oscillations in NREM sleep are coupled with enhanced memory performance and vascular dynamics,20,21 and NE is a potent vasoconstrictor, pointing toward the idea that NE oscillations may drive glymphatic flow during NREM sleep.23 We therefore asked whether NE oscillations in APP/PS1 mice differ from those in WT mice. Here, APP is linked to Alzheimer disease.