In agreement, altered nuclear dynamics and modifications of chromatin have been observed in multiple neurological disorders along with AD.65–67 Interestingly, we identified one protein candidate previously listed among AD biomarkers, namely microtubule-associated protein tau (Mapt), which was elevated in naturally sleeping APP/PS1 mice compared to WT (Figure 5I).62 Together, the overall proteome during natural sleep reflects subtle changes in pathological AD biomarkers already during early stages of amyloidosis. Here, PSEN1 is linked to Alzheimer disease.