Among the low PlGF level cohort, the adjusted relative risk for iatrogenic early preterm birth was 92.11 (95% CI, 64.83-130.87; P < .001) and the adjusted difference in mean gestational age at birth was 6.10 (95% CI, 5.80-6.39) weeks earlier compared with the reference range PlGF level cohort (P < .001), while the rate of stillbirth was more than 10% (aRR, 36.78 [95% CI, 18.63-72.60]; P < .001), and the rate of preeclampsia, nearly 50% (aRR, 11.01 [95% CI, 8.85-13.69]; P < .001). The gene discussed is PGF; the disease is preeclampsia.