We did not observe differences in PMBC Il1 expression, but osteoclastic overexpression of IL-1 Receptor is in line with previous reports showing increased circulating Il1 (and subsequent Il18) levels in cystinotic patients, compared to patients with Familial Mediterranean fever, probably due to endogenous inflammasome activation by cystine crystals [8]. The gene discussed is IL1B; the disease is brucellosis.