In preclinical models of AD, the microglial profile in the early stages have a homeostatic signature, identified with expression of genes such as purinergic receptor (P2ry12), C-X3-C motif chemokine receptor 1 (Cx3cr1) and transmembrane protein 119 (Tmem119) [20], and ramified morphology as observed with ionised calcium-binding adaptor 1 (Iba1) [3]. Here, TMEM119 is linked to Alzheimer disease.