CD8A and neoplasm: To determine the mechanism by which modulation of Uba1 expression affected tumor growth in a CD8+ T cell–dependent manner, we performed RNA-seq analysis on tumors with Uba1 depletion or overexpression and found that both type-I and type-II IFN signaling pathways were among the most deregulated pathways in tumors with modulated Uba1 expression (Fig. 5A and B; Supplementary Fig. S5A and S5B).