UBA1 and neoplasm: To determine whether this antitumor effect was immune dependent, we depleted CD8+ T cells with an anti-CD8 antibody (Supplementary Fig. S2C) and observed that depletion of CD8+ T cells significantly, albeit partially, rescued the growth of Uba1-depleted tumors (Supplementary Fig. S2D), showing that CD8+ T cells were indispensable for the full tumor control mediated by Uba1 depletion.