Of note, the top positively correlated list included genes expressed in functional CD8+ T cells [highlighted in blue in Supplementary Fig. S1A (left)], confirming the reliability of the dataset, whereas the top negatively correlated list included many genes that have been reported to mediate immune evasion or were associated with a cold tumor microenvironment [highlighted in pink in Supplementary Fig. S1A (right)]. The gene discussed is CD8A; the disease is neoplasm.