ALOX5 and hepatocellular carcinoma: For example, as reported by Yong‐Jiang Xu et al., eicosanoids derived from arachidonic acid, including PGE2 (prostaglandins E2), 5‐LOX (5‐lipoxygenase), 12‐HETE (12‐hydroxyeicosatetraenoic acid), and 15‐HETE, elevated hepatic inflammation as well as liver regeneration, thus favoring HCC progression [38].