Then, we performed univariate Cox regression analysis to identify survival‐related genes in the TCGA‐LIHC training dataset, and the results revealed 12 genes participating in arachidonic acid metabolism (GPX4, GGT7, PTGES2, AKR1C3, PTGS1, HPGDS, TBXAS1, GPX7, PTGES, CYP2C8, CYP4A11, and CYP2C9) as potential prognostic indicators of OS of patients with HCC, nine of which were risk factors and three were protective (Figure S1A). This evidence concerns the gene GPX4 and hepatocellular carcinoma.