We then determined the combined effect of GNA and the MCL-1 inhibitor MIK665 (S64315).21 As compared with GNA alone, the combination led to a further suppression of cell proliferation (Figure 3a,b) and a further increase of caspase 3/7 activity (Figure 3c,d) in MDS-L, SKM-1, MDS-EB1, and MDS overt AML cells. This evidence concerns the gene CASP3 and myelodysplastic syndrome.