In the univariate analysis, several factors emerged as significant negative predictive factors for postoperative RFS, including TIGIT+(p = 0.021), NKG2A+(p = 0.026), intraoperative blood loss ≥ 400 mL (p = 0.003), tumor size ≥ 5 cm (p = 0.014), presence of vascular tumor embolus (p < 0.001), absolute value of lymphocyte count (p = 0.024), and BCLC stage B‐C (p < 0.001). This evidence concerns the gene TIGIT and neoplasm.