Collagen triple helix repeat containing 1 (CTHRC1) is a secreted extracellular matrix glycoprotein and originally identified in balloon‐injured arteries.[22] It is widely reported to extensively participate in a variety of physiological and pathological processes.[23] Previous studies have demonstrated the significant role of CTHRC1 in the repair of various injuries, such as vascular remodeling,[22, 24] post‐myocardial infarction repair,[25, 26] and skin wound healing.[27, 28] However, the potential role and underlying mechanism of CTHRC1 in tendinopathy remain unknown. The gene discussed is CTHRC1; the disease is disease of the tendon.