By practice, nonetheless, we did confirm that sACE2 could mediate cell entry of the SARS-CoV-2 (20) and its level may reflect membrane-bound mACE2 content (41), in addition to all the 16 publications validating the reliability of the Abcam Human SimpleStep ELISA® Kit studying the pathogenesis of ACE2 in COVID-19 (49). This evidence concerns the gene ACE2 and COVID-19.