The merged data from GSE95233 and GSE57065 showed a significant decrease in the expression of DNMT1 and TP53 in the sepsis group compared to the control group, while the expression of TLR8 was significantly elevated in the sepsis group (Figure 5A), and the ROC analysis found the AUC to be 0.979, 0.967, and 0.944 for DNMT1, TP53, and TLR8, respectively (Figure 5D). Here, TLR8 is linked to Sepsis.