Liver stiffness was measured by transient elastography using 13 and 21 kPa as cutoffs (liver stiffness of ≥13 kPa but ≤21 kPa was associated with the diagnosis of cirrhosis) and thrombin generation was assessed by the ST Genesia® Thrombin Generation System (STG) using Thromboscreen with or without thrombomodulin (TM) and calibrated automated thrombography (CAT) using low PPP reagent (5 pmol/L TF and 4 pmol/L phospholipids) (Stago, Asnières sur Seine Cedex France) with or without TM. This evidence concerns the gene THBD and Cirrhosis.