Moreover, coagulopathy mirrors the extent of hepatic function damage, as prolonged prothrombin time indicates a poor prognosis in acute liver failure, while in liver cirrhosis staging, prothrombin time is utilized for calculating the Child-Pugh score. Although coagulation tests are abnormal in chronic liver disease, bleeding events happen mainly through variceal bleeding due to poor synthesis of anticoagulant factors in the insufficient liver [19]. This evidence concerns the gene F2 and acute liver failure.