By using a threshold at week 2 of 7.9 IFN-γ IU/mL, the 1-year bacterial infection-free survival curve of patients with low response was more clearly separated from those above the cut-off (Supplementary Figure S2), yielding improved specificity [66.7% (95% CI: 53.9–77.8)] and PPV [57.7% (95% CI: 47.8–66.9)] at the expense of a loss of sensitivity [68.2% (95% CI: 52.4–81.4)]. This evidence concerns the gene IFNG and bacterial infectious disease.