Of the 27 patients who presented with multiple PGLs at the time of their genetic counseling consultation, 24 completed genetic testing and 19 (79.2%) tested positive for an LPV/PV in a hereditary cancer gene, all of which were in PGL/PCC genes (SDHD = 13, SDHB = 4, SDHC = 2). The gene discussed is SDHB; the disease is cancer.