NR3C1 and obesity due to melanocortin 4 receptor deficiency: Stress-induced release of corticosterone from the adrenal cortex in rodents has been linked to obesity on a high-fat diet (Hueston and Deak, 2020; Kinlein et al., 2019; Lowrance et al., 2016; Qiu et al., 2019), at least in part because corticosterone hyperactivates glucocorticoid receptors in adipose tissue, leading to lipid accumulation (Appiakannan et al., 2020; Gado et al., 2023).