At the same time, the hyperactivation of glucocorticoid receptors can cause inflammatory response (Bharti et al., 2019; Ferguson et al., 2020; Shimba and Ikuta, 2020; Wu et al., 2021), which may explain why levels of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6 were significantly higher in the presence of stress-induced obesity than in its absence. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.