The results revealed that the PTPRD-AS1-NTF4-PI3K/AKT signaling pathway and the three trans-regulatory lncRNAs (HID1-AS1, RASGRF-AS1, TBX2-AS1) regulated the ITGA11 in trans. The previous study has identified PTPRD-AS1 as a novel lncRNA involved in bladder cancer, with associations with immune-related processes [67,68]. The gene discussed is NTF4; the disease is urinary bladder carcinoma.