NFATC2 and obesity due to melanocortin 4 receptor deficiency: Compared with normal women, the CD4+ T cell activation-related genes JUN, NFATC2, SOS1, AKT, and MAPK9 in patients with PCOS and obesity were upregulated and enriched in the T cell receptor (TCR) signaling pathway, FoxO signaling pathway, Th17 cell differentiation signaling pathway, and Th1 and Th2 cell differentiation pathways, as depicted in Figure 3.